Btg3 and p53
Webp53. Target Genes. Recent genome-wide analyses and meta-analyses of genome-wide datasets of p53 DNA-binding and gene regulation show that p53 is a direct activator of a limited number of genes compared to the number of putative response-elements identified genome-wide. They also provide evidence that p53 is not a direct repressor of genes . WebAug 9, 2007 · Proper regulation of cell cycle progression is pivotal for maintaining genome stability. In a search for DNA damage-inducible, …
Btg3 and p53
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WebNov 18, 2014 · When DNA is damaged, p53 is upregulated, which will induce DNA repair and cause the cell cycle arrest at G1/S-phase. If damage cannot be repaired, p53 will induce programmed cell death or apoptosis. It has been demonstrated that BTG2 exerts its antitumor effect through p53-dependent Ras signal transduction pathway . Thus, the … Webbtg3在g1期表达量最高，g1-s期表现出峰值[16]。 BTG3表达缺失与肺癌的发生有关[17]，也能增强BMP诱导的骨形成[18]。 肌肉生长抑制素(Myostatin，MSTN) 基因是TGF-β超家族成员，是骨骼肌生长的负调控因子，为生长发育性状的候选基因。
WebJun 1, 2024 · BTG3 (B-cell translocation gene 3), a candidate tumor suppressor gene, is a member of the antiproliferative BTG/Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and CHK1-dependent manner (Cheng et al., 2013). WebOther articles where TP53 is discussed: tumour suppressor gene: …tumour suppressor genes (such as TP53, which encodes a protein known as p53) have been identified. The mutated form of TP53 has been implicated in …
WeblncRNA MEG3、miR-373-5p引物均购自上海吉凯制药有限公司；Lipofectamine2000转染试剂购自重庆市华雅干细胞技术有限公司；DMEM培养基购自上海微科生物技术有限公司；牛血清、0.25%胰蛋白酶均购自上海素尔生物科技有限公司；鼠抗人BTG3单克隆抗体购自上海圻明生物科技 ... WebAug 9, 2007 · Proper regulation of cell cycle progression is pivotal for maintaining genome stability. In a search for DNA damage-inducible, CHK1-modulated genes, we have identified BTG3 (B-cell t ranslocation g ene 3) as a direct p53 target. The p53 transcription factor binds to a consensus sequence located in intron 2 of the gene both in vitro and in vivo, …
WebDec 4, 2024 · BTG3 is a direct downstream target of miR-106b-5p. BTG3 overexpression inhibited tumor growth of SW620 cells by suppressing proliferation and inducing …
WebOct 1, 2007 · BTG3 protein is induced by DNA damage in a p53-dependent manner. ( A ) BTG3 in LNCaP cells is induced by various DNA damage agents. Cells were treated with 8 Gy of X-ray (lanes 2–4), 0.5 mM of H ... cod reducere r golWebFeb 1, 2000 · Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was induced in response to DNA damage … cod reducere skymapWebFeb 19, 2024 · PDF BTG4 is the last cloned and poorly studied member of BTG/Tob family. Studies have suggested that BTG4 is critical for the degradation of maternal... Find, read and cite all the research ... calvary creeksideWebp53 regulated genes curated by M. Fisher (Fischer M. Census and evaluation of p53 target genes. Oncogene. 2024; 36: 3943-3956. PMID: 28288132 ). All genes have been converted to mouse. Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood ... cod reducere smykcod reducere sport selectWebDec 11, 2024 · B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53. Here, we show that senescence … calvary day school girls soccerWebGal-3 is down-regulated by wt-p53 and this repression is required for p53-induced apoptosis. Since poorly differentiated thyroid carcinomas (PDTCs) and anaplastic thyroid … cod reducere shein