WebJan 1, 2024 · DHCR7 activity was significantly decreased when we used pharmacological inhibitors against two important kinases, AMP-activated protein kinase and protein … WebThese microsomes contained negligible levels of POR but had 2.5-fold greater DHCR7 activity than did microsomes from wild-type mice. Consistent with this greater activity, immunoblot analysis of DHCR7 expression indicated that DHCR7 protein levels were elevated 2-fold in POR-null microsomes. Addition of POR to these microsomes provided …
DHCR7 gene: MedlinePlus Genetics
Webthe DHCR24 gene is knocked down by siRNA, DHCR7 activ-ity is also ablated. Conversely, overexpression of DHCR24 enhances DHCR7 activity, but only when a functional form … WebDescription: Homo sapiens 7-dehydrocholesterol reductase (DHCR7), transcript variant 1, mRNA. (from RefSeq NM_001360) RefSeq Summary (NM_001360): This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed … phoenix in naruto
Cholecalciferol increases 7‐dehydrocholesterol reductase activity …
WebJul 12, 2016 · Several anti-psychotic drugs were found to enhance DHCR7 activity. 57, 58, 59 Other drugs, not otherwise known to modulate … WebThe highest levels of DHCR7 expression have been detected in the adrenal gland, the testis, the liver and in brain tissue. Its expression is induced by decreased sterol concentrations via sterol regulatory binding proteins (SREBP). There is also evidence that its activity may be regulated by tissue specific transcription, and alternative splicing. WebJan 14, 2024 · DHCR7 deficiency or treatment with the natural product 7-dehydrocholesterol (7-DHC) could specifically promote phosphorylation of IRF3 (not TBK1) and enhance type I interferon (IFN-I) production in macrophages. We further elucidated that viral infection or 7-DHC treatment enhanced AKT3 expression and activation. AKT3 directly bound and ... ttm software