Ion channel trafficking
Web1 jan. 2014 · The functional modulation of several ion channels are altered during oxidative stress conditions associated with cardiac arrhythmogenesis, colonic inflammation, diabetes, etc. (Table 15.1 ). In some cases, this can be beneficial while in others lead to pathological states. Ion channels may also act as redox sensors. WebAssociate Professor. Wake Forest School of Medicine. 2016 - May 20245 years. Greensboro/Winston-Salem, North Carolina Area. My group …
Ion channel trafficking
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Web14 dec. 2024 · This review summarizes the different trafficking mechanisms underlying the polarized Na v channel localization in neurons, with an emphasis on the axon initial … Web1 dec. 2009 · Ion channels are integral membrane proteins that allow the movement of ions across cell membranes. They play an important role in physiological functioning of cells …
WebDrug-induced ion channel trafficking disturbance can cause cardiac arrhythmias. The subcellular level at which drugs interfere in trafficking pathways is largely unknown. K … Web1 jul. 2006 · The appropriate targeting of voltage-gated ion channels is essential for the normal functioning of neurons. Lai and Jan review the mechanisms involved in the trafficking and retention of these ...
WebRESEARCH INTEREST: Our research focuses on how subunits that are part of the cardiac voltage-gated sodium channel localize at the cell surface. NaV1.5 is the pore-forming α subunit, and its trafficking and activity are regulated by associated β subunits, as well as by other components of the channel; their proper localization is imperative for adequate ion … Web14 mei 2024 · The properties of ion channels can be studied by means of the patch clamp technique. A very fine pipette (with an opening of about 0.5 µm) is pressed against the …
WebOverview. Functional ion channel activity can be hindered by prolonged exposure to drugs that inhibit trafficking of the channel protein from cytoplasmic sites to the surface …
WebDefects in ion channel function underlie an emerging class of human genetic diseases, termed channelopathies. In addition to other sensory … flip hairstyle boysA fascinating question relates to the nature of the molecular mechanisms which regulate ion channel targeting into distinct subdomains of the sarcolemma and their tethering in large molecular complexes. Cardiac myocytes are structurally and functionally highly polarized cells. While the transmission … Meer weergeven The function of the heart is governed by the electrical and mechanical activity of myocytes. The functional expression of several different types of ion channels in the myocyte … Meer weergeven The IKr current is encoded by the human ether-a-go-go–related gene (HERG, also known as KCNH2) in the heart (Sanguinetti … Meer weergeven Cardiomyocytes are exposed to mechanical forces when the heart contracts. These forces consist of stretch, shear and … Meer weergeven Cardiac excitability can be regulated by cellular lipid content. Free cholesterol is a major lipid class shown to regulate membrane fluidity, curvature, and stiffness (Lundbaek et al., 1996). The function of several … Meer weergeven greatest british novelsflip handheld camcorderWebKv4.2 voltage-gated K + channel subunits, the primary source of the somatodendritic A-type K + current in CA1 pyramidal neurons of the hippocampus, play important roles in regulating dendritic excitability and plasticity. To better study the trafficking and subcellular distribution of Kv4.2, we created and characterized a novel Kv4.2 construct encoding a bungarotoxin … greatest british novels of 20th centuryWeb2 apr. 2013 · A growing number of drugs interfere with normal trafficking of ion channels to and from the plasma membrane, thereby altering the number of channels on the cell … greatest british paintersWebChapter 23 TRP Channel Trafficking Rosa Planells-Cases and Antonio Ferrer-Montiel. Author Information Cellular function, in particular neuronal activity, is the result of an orchestrated interplay between membrane … flip handheld deviceWebAt the department of Medical Physiology, we focus on trafficking of the repolarizing ion channels that underlie IKr and IK1. We are beginning to learn that ion channels traffic … greatest british novels of all time