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Lamp2b

Tīmeklis研究mirna的靶点mrna，构建过表达质粒，是否需要考虑3‘utr区，还是只过表达cds区就行了？. rt，因为mirna和mrna的3’utr区结合，过表达是仅过表达cds区是不是没有效果？是不是要包含3‘utr区？. 丁香园-核酸基因技术-2024-05-03 09:48:59 Tīmeklis2024. gada 24. dec. · Here, we demonstrate that LAMP-2B promotes autophagosome–lysosome fusion in cardiomyocytes (CMs), independently of STX17. …

Systemic AAV9.LAMP2B injection reverses metabolic and …

Tīmeklis2024. gada 23. maijs · The expression of CTP-Lamp2b peptide on exosomes was stabilized by attaching glycosylation sequences. Exosomes expressing only Lamp2b … TīmeklisRP-A501 is an investigational gene therapy product being developed for Danon Disease and the first potential gene therapy for monogenic heart failure. It consists of a recombinant adeno-associated serotype 9 (AAV9) capsid containing a functional version of the human LAMP2B transgene (AAV9.LAMP2B). RP-A501 is currently being … girl in the basement po polsku cda https://ticohotstep.com

Addgene: pcDNA GNSTM-3-RVG-10-Lamp2b-HA

Tīmeklis2024. gada 1. febr. · 本发明属于基因工程技术领域，具体涉及一种LDLR-Lamp2b融合基因、表达载体及其应用。背景技术心血管疾病位列当前威胁人类健康的三大疾病，即心血管疾病、肿瘤和传染性疾病之首，而动脉粥样硬化又是心血管疾病的最重要的病理学基础之一，是引起心肌梗塞、脑梗塞以及冠心病等心脑血管疾病 ... Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the cell. Some of this is done via acid … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and … Skatīt vairāk Tīmeklis2024. gada 21. marts · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Left … function of the cytoplasm in an animal cell

Stabilization of Exosome-targeting Peptides via Engineered ...

Category:Systemic AAV9.LAMP2B injection reverses metabolic and …

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Lamp2b

一种LDLR-Lamp2b融合基因、表达载体及其应用的制作方法

Tīmeklis2024. gada 4. aug. · For example, lysosome-associated membrane protein 2b (Lamp2b) is an exosomal surface protein with an exosomal signal peptide. Fusion of a protein of interest to Lamp2b is very common for displaying the protein on the surface of exosomes as a targeting moiety, ligand, or receptor. A Lamp2b-based fusion … Tīmeklis2011. gada 20. marts · FLAG-Lamp2b was strongly expressed in dendritic cells and was incorporated into the dendritic cell–derived exosomes based on western blots with anti-FLAG and anti-Lamp2b antibodies . As the ...

Lamp2b

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TīmeklisPlasmid pcDNA Flag Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: … Tīmeklis2024. gada 6. sept. · Lamp2b alone or fusion protein was cloned into pcDNA 3.1(-) similarly as described before . For Lamp2b-empty vector construction, the Lamp2b CDS was amplified using corresponding primers, followed by direct clone into pcDNA 3.1(-). For HuR-Lamp2b vector construction, Xho1 and BspE1 cloning sites were …

TīmeklisCD51 + CD61 (Integrin alpha V + Integrin beta 3) CD51 / Integrin alpha V. CD52 TīmeklisPlays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the …

Tīmeklis2024. gada 24. nov. · Lamp2b-HuR融合蛋白功能化的外泌体能够将被RNA结合基序识别的RNA靶标驱动至溶酶体以在受体细胞中降解。 该系统在富含溶酶体的巨噬细胞中 … Tīmeklis2024. gada 15. nov. · 细胞外小囊泡（ sEVs RVG ） 的脑部 神经特异性靶向是通过 将 s EVs膜蛋白lamp2b 和 神经 靶向 性的狂犬病毒糖蛋白衍生肽（RVG） 融合 递呈在 细胞外囊泡 上， 在细胞及动物水平验证了 sEVs RVG-siRNA 的抗病毒能力. 图3： sEVs RVG-siRNA 装载siRNA条件的优化及 其在细胞水平 ...

Tīmeklis2024. gada 7. maijs · 溶酶体相关膜蛋白2b（lysosome-associated membrane protein 2b，Lamp2b）是一个外泌体膜蛋白。通常将靶分子和Lamp2b进行融合，通过lamp2b,展示到外泌体膜表面。 lamp2b-RVG (RVG为一个神经特异性靶向肽），可以将外泌体导向到神经系统。 除了lamp2b外，还有CD63,CD9, CD81,GPI,PDGFRs等。

TīmeklisLAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C. LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer using a recombinant adeno-associated virus 9 carrying human LAMP2B (AAV9.LAMP2B) in a Lamp2 knockout (KO) mouse, a DD model. function of the discharge summaryTīmeklis2015. gada 27. marts · Indeed, peptides fused to the N terminus of exosome-associated transmembrane protein Lamp2b were cleaved in samples derived from both cells and exosomes. To suppress peptide loss, we engineered targeting peptide-Lamp2b fusion proteins to include a glycosylation motif at various positions. Introduction of this … function of the eaabTīmeklis一种基于Lamp2b的融合蛋白可用于在表面显示狂犬病病毒糖蛋白（RVG），当这些胞外体被系统地给予时，表面展示的RVG导致这些胞外体在小鼠的神经元和大脑中积聚 … girl in the basement rotten tomatoesTīmeklis2024. gada 18. marts · LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer … function of the ecjTīmeklis2024. gada 13. maijs · Recently, RVG has been engineered to exosomal surface via fused protein lysosome-associated membrane glycoprotein 2b (Lamp2b)-RVG in order to achieve neuron-specific targeting . Furthermore, the modified exosomes, with RVG fused to exosomal protein Lamp2b, could efficiently deliver miR-124 to the infarct … function of the duodenum in digestionTīmeklisPlasmid pCDNAHygro(+)LAMP2B from Dr. Janice Blum's lab contains the insert Lysosome-associated membrane protein 2b and is published in Immunity. 2005 May;22(5):571-81. This plasmid is available through Addgene. Image: Illustrated plasmid map in PNG format. GenBank File: Plasmid sequence and annotations. Use text … girl in the basement real photosTīmeklis2024. gada 8. janv. · Here, we identify the LAMP-2 isoform B (LAMP-2B) as required for autophagosome-lysosome fusion in human cardiomyocytes (CMs). Remarkably, LAMP-2B functions independently of syntaxin 17 (STX17), a protein that is essential for autophagosome-lysosome fusion in non-CMs. Instead, LAMP-2B interacts with … function of the epidermis in the anther